Soluble Toll-like Receptor 2 (sTLR2) in Sepsis and Inflammation

Understanding and managing systemic inflammatory responses, including sepsis, often requires advanced diagnostic techniques. The sTLR2 RAPID Test provides a fast, semi-quantitative measurement of soluble Toll-like Receptor 2 (sTLR2), a critical innate immune biomarker in plasma. This assay is designed to support both fundamental immunological research and clinical assessment of acute inflammatory conditions.

Unlocking Early Immunological Responses with sTLR2

Sepsis and systemic inflammation pose profound challenges in critical care and beyond. Early, precise immunological assessment is key. Soluble Toll-like Receptor 2 (sTLR2) functions as a pivotal innate immune biomarker, reflecting the immediate host response to diverse pathogenic and sterile insults. The proprietary IMIWN sTLR2 RAPID Test facilitates rapid, semi-quantitative measurement of this immune mediator, designed for easy integration into research protocols and clinical decision pathways.

Key Immunological Implications of sTLR2

  • Rapid Kinetic Response: sTLR2 levels show rapid elevation following immune insults, enabling assessment of acute inflammatory responses within minutes, which may precede conventional biomarkers
  • Mechanistic Insight: Quantification of sTLR2 provides a direct measure of its role in modulating Toll-like Receptor signaling, a fundamental aspect of innate immunity
  • Translational Potential: Studies exploring the utility of sTLR2 in patient stratification, prognosis, and monitoring of therapeutic interventions in complex inflammatory states
  • Empirical Evidence: The physiological and pathological roles of sTLR2 are supported by extensive peer-reviewed literature, underscoring its relevance in sepsis pathogenesis and general inflammatory processes.

IMIWN sTLR2 RAPID

The IMIWN sTLR2 RAPID test is a UKCA certified in vitro diagnostic immunochromatographic (lateral-flow) assay for the semi-quantitative measurement in plasma of human soluble Toll-like receptor 2 (sTLR2) - a biomarker of sepsis and other inflammatory conditions. The level of sTLR2 in plasma has the potential to provide additional information to that of traditional biomarkers such as C-reactive protein (CRP) and procalcitonin (PCT).

Quality Assurance and Compliance

The sTLR2 RAPID Test, developed and manufactured in the UK under a certified ISO 13485:2016 quality management system, is UKCA certified and registered with MHRA, demonstrating our commitment to providing high quality reagents and diagnostics.

Immunologists, researchers, and clinicians: explore the science behind sTLR2, and its potential applications in diagnosing and managing critical immune conditions.

IMIWN sTLR2 lateral flow test cassette showing two magenta coloured lines for test and control respectively.

Results in 10 minutes

Semi-quantitative results from a 20µL plasma or serum sample in 10 minutes (whole blood version available from Q3/2025). The human sTLR2 rapid test kit uses proprietary sTLR2 monoclonal antibodies in a simple, convenient lateral flow format. Each kit contains 10 test devices.

sTLR2 RAPID Overview & Features
Lateral flow assay development showing a close up of a dispensor for positive and negative controls of the sTLR2 RAPID test.

Quality assured

Developed and manufactured in the UK according to a fully certified medical device quality assurance system (ISO13485).

UKCA Certified. Registered with MHRA.

Quality & Certifications